孫學(xué)軍報(bào)道：氫氣和輻射防護(hù)

關(guān)于氫氣治療疾病的研究報(bào)道幾乎每周都有更新內(nèi)容，最近關(guān)于各個(gè)領(lǐng)域的綜述性文章也逐漸增多。剛剛在Free Radic Res. 2012 Apr 27在線發(fā)表一篇關(guān)于氫氣和輻射防護(hù)的綜述。主要針對氫氣在輻射損傷方面的研究，這個(gè)方面不僅具有民用價(jià)值，而且軍事價(jià)值也顯著，美國太空總署更是把氫氣作為太空輻射防護(hù)的一種手段，并開展了相關(guān)研究。

氫分子作為一種選擇性清除毒性自由基羥基自由基的優(yōu)質(zhì)抗氧化物質(zhì)，其有效性被大量的動物疾病模型和臨床疾病研究中被反復(fù)證明。眾所周知，輻射可以使生物體內(nèi)水被激發(fā)大量產(chǎn)生羥基自由基，導(dǎo)致的氧化損傷和細(xì)胞凋亡，是輻射損傷的最基本病理生理過程。第二軍醫(yī)大學(xué)放射醫(yī)學(xué)研究室在國際上率先報(bào)道了氫氣在細(xì)胞和小鼠輻射損傷中顯著保護(hù)作用。該效應(yīng)隨后被他們和國際同行在不同的輻射損傷模型中被證實(shí)。最近的雙盲對照臨床研究發(fā)現(xiàn)，氫氣水對肝臟腫瘤患者臨床放射治療引起典型的人類輻射損傷副作用具有保護(hù)作用，可提高患者的生活質(zhì)量。這些研究結(jié)果顯示，氫氣可以作為一種有效無毒的輻射防護(hù)劑

Free Radic Res. 2012 Apr 27. [Epub ahead of print]

Molecular hydrogen and radiation protection.

Chuai Y, Sun X, Cai J.

Abstract Molecular hydrogen (dihydrogen, H(2)) acts as a therapeutic antioxidant by selectively reducing hydroxyl radicals (?OH) and peroxynitrite (ONOO-). It has been well-known that ionizing radiation (IR) causes oxidative damage and consequent apoptosis mainly due to the production of ?OH that follows radiolysis of H(2)O. Our department reported the protective effect of H2 in irradiated cells and mice for the first time, and this effect is well repeated by ourselves and another laboratory in different experimental animal models. A randomized, placebo-controlled investigation also showed consumption of H(2) can improve the quality of life of patients treated with radiotherapy for liver tumors. These encouraging results suggested that H(2) has a potential as a radioprotective agent with efficacy and non-toxicity.

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